Palmitoyl Tripeptide-38 is a synthetic tripeptide used in cosmetics as a skin-care active ingredient for “well-aging.” As a matrikin-like peptide, it can target signaling pathways in the extracellular matrix and thereby smooth the skin’s texture: Manufacturer data report a visible reduction in fine lines (e.g., forehead, crow’s feet) with regular use. Palmitoyl Tripeptide-38 is a so-called matrix peptide that stimulates the production of key components of the skin matrix—including collagen I, III, and IV, as well as hyaluronic acid.(1) These structures provide the skin with elasticity and firmness. In clinical studies, Palmitoyl Tripeptide-38 was shown to visibly reduce wrinkle depth. In formulations, it thus helps maintain healthy skin and a more even skin texture.(1-3)