Palmitoyl Tripeptide-38 is a synthetic peptide consisting of the amino acids lysine, methionine, and lysyl, bound to palmitic acid. Palmitoyl Tripeptide-38 is a component of the complex known as Volulip™. In the manufacturer’s in vivo studies, twice-daily application of a product containing 1% Volulip™ resulted in a visible improvement in the appearance of the lips (smoothness, curvature, surface texture, and volume), as well as in hydration and youthfulness (more defined contours and a plumping effect), in at least 69% of the female participants.(2) It belongs to the class of “matrikin-mimetic compounds,” which play a key role in the synthesis of elastin and collagen. In addition, it can stimulate cell proliferation. Palmitic acid, as an ingredient, also has antioxidant properties. It is considered suitable for use in cosmetic products and has been classified as safe in a safety assessment of cosmetic ingredients.(1)