Palmitoyl tripeptide-1 is a peptide obtained as the reaction product of palmitic acid and tripeptide-1. Together with palmitoyl tetrapeptide-7, it is also known as Matrixyl™3000 and consists of a short peptide chain containing three amino acids (glycine, histidine, and lysine = GHK peptide) bound to the fatty acid palmitic acid.

In ex vivo studies, Palmitoyl Tripeptide-1 has been shown to have the ability, on its own, to stimulate the synthesis of type 1 collagen in the body and to prevent collagen breakdown following UVA exposure.(1) In studies, Matrixyl™3000 has been shown to result in a statistically significant reduction in wrinkle length and depth, as well as skin roughness, and an increase in skin thickness.(2)