PALMITOYL PENTAPEPTIDE-4
Palmitoyl pentapeptide-4 is a peptide derived from the reaction between palmitic acid and pentapeptide-4. It is also known as Matrixyl and consists of a short peptide chain containing five amino acids (lysine, threonine, threonine, lysine, serine) bound to palmitic acid.
Palmitoyl pentapeptide-4 is a biologically active peptide that has been reported to stimulate the production of elastin, fibronectin, glucosaminoglycans, and collagens (particularly types I, III, and IV), as well as to support wound healing.1 In studies, it has been shown to be effective in reducing periorbital wrinkles by decreasing wrinkle depth and improving skin barrier function and skin elasticity.(1-3)
(1) Schagen, S. K. (2017). Topical peptide treatments with effective anti-aging results. Cosmetics, 4(2), 16.https://doi.org/10.3390/cosmetics4020016
(2) Suhendra, N. N. (August 2020). The efficacy of 7% palmitoyl pentapeptide-4 serum for the reduction of periorbital wrinkles. In Rangsit Graduate Research Conference: RGRC (Vol. 15, No. 2563), pp. 2870–2884.
(3) Aruan, R. R., Hutabarat, H., Widodo, A. A., Firdiyono, M. T. C. C., Wirawanty, C., & Fransiska, L. (2023). Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet. The Journal of Clinical and Aesthetic Dermatology, 16(2), 37–43.
