Hyaluronic acid is one of the primary factors in skin hydration, along with lipids, natural moisturizing factors, sebum, and aquaporin. As the predominant component of the extracellular matrix, hyaluronic acid plays an essential role in maintaining skin hydration. Hyaluronic acid is produced as early as the embryonic development stage, making it one of the first components of the extracellular matrix. In addition to its ability to bind water, the molecule acts as a lubricant during skin movements between the collagen and elastic fiber networks in the dermis. Furthermore, hyaluronic acid can influence cellular metabolism.(1)