ASCORBYL TETRAISOPALMITATE
Ascorbyl tetraisopalmitate is a vitamin C derivative and is used in cosmetics to prevent skin aging due to its antioxidant properties.(1) It has a high affinity for the stratum corneum of human skin and is also capable of promoting collagen synthesis in deeper cells.(2-3) In a 2021 study, when combined with other substances such as rice peptides, it was shown to increase skin hydration, reduce hyperpigmentation, and promote cell renewal in the epidermis.(4)
(1) Almeida, M., Lima, C., Quenca-Guillen, J., Filho, E., Mercuri, L., Santoro, M., & Kedor-Hackmann, É. (2010). Stability evaluation of tocopheryl acetate and ascorbyl tetraisopalmitate in isolation and incorporated in cosmetic formulations using thermal analysis. Brazilian Journal of Pharmaceutical Sciences, 46, 129–134.
(2) Machado, N., Santos, L., Carvalho, B., Singh, P., Soto, C., Azoia, N., Cavaco-Paulo, A., Martin, A., & Fávero, P. (2016). Assessment of the penetration of ascorbyl tetraisopalmitate into biological membranes using molecular dynamics. Computers in Biology and Medicine, 75, 151–9.
(3) Dulińska-Molak, I., Pasikowska-Piwko, M., Dębowska, R., Święszkowski, W., Rogiewicz, K., & Eris, I. (2019). Determining the effectiveness of vitamin C in skin care using an atomic force microscope. Microscopy Research and Technique, 82, 1430–1437.
(4) Shirata, M., & Campos, P. (2021). Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized, Placebo-controlled Clinical Study. Photochemistry and Photobiology, 97.
